… of PCD with randomization of left-right asymmetry was … PCD causing genes with autosomal
recessive inheritance. … disease causing variants in CP associated genes such as HYDIN lack …

… The first international randomized controlled trial in PCD has … As an example HYDIN-mutant
sperm cells are predominantly … recessive fashion and biallelic pathogenic mutations are …

… axoneme was not altered in C11orf70 mutant cilia (Figure S8). However, TTC25 localization
along the ciliary axoneme was not altered … Recessive HYDIN mutations cause primary ciliary …

… -recessive or X-linked disorder caused by mutations in genes … with previous studies except
that HYDIN other than DNAI1 is … or Europe do not screen for HYDIN mutations or have limited …

… an autosomal-recessive pattern and encoding a ciliary protein in … residing in HYDIN and not
in HYDIN2, but we did not perform copy … SPEF2- and HYDIN-mutant cilia lack the central pair-…

… includes a myriad of left-right organ laterality defects and … disease-causing variants in
HYDIN or in other CA genes may … (CLEAN-PCD): a multinational, phase 2, randomised, double…

… a strong history for PCD but do not follow the “norm”, we … HYDIN mutation is an excellent
example where tomography … are associated with randomisation of left–right asymmetry or situs …

… , as cilia are important in the left–right symmetry during … HYDIN mutations in PCD patients
can present with abnormal … A multicentre randomised trial of prophylactic azithromycin …

… the HYDIN axonemal central pair apparatus protein and biallelic HYDIN variants cause PCD
… Unlike most other PCD genes, recessive HYDIN variants do not cause laterality defects, but …

… PCD is predominantly inherited as an autosomal recessive … composure of the central pair
(HYDIN), radial spokes (RSPH1, … with randomization of left/right body asymmetry. Am J Hum …